BOSTON – Thiazolidinediones (TZD's) are drugs commonly prescribed to
patients with type 2 diabetes, the most common form of diabetes.
Current U.S. Food and Drug Administration-approved agents are known as
Actos (pioglitazone) and Avandia (rosiglitazone). These oral agents
improve blood glucose levels in people with diabetes by improving
insulin action in the body. While it is known that these drugs work
primarily by binding to a receptor in the nucleus of cells called
Peroxisome Proliferator Activated Receptor-gamma (PPARg), all of the
molecular signaling events important for the drugs to work are not
completely understood.
patients with type 2 diabetes, the most common form of diabetes.
Current U.S. Food and Drug Administration-approved agents are known as
Actos (pioglitazone) and Avandia (rosiglitazone). These oral agents
improve blood glucose levels in people with diabetes by improving
insulin action in the body. While it is known that these drugs work
primarily by binding to a receptor in the nucleus of cells called
Peroxisome Proliferator Activated Receptor-gamma (PPARg), all of the
molecular signaling events important for the drugs to work are not
completely understood.
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